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7.7. Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons

C Perdices-Lopez , MS Avendano , A Barroso , F Gaytan , F Ruiz-Pino , MJ Vazquez , S Leon , YB Song , V Sobrino , V Heras , A Romero-Ruiz , J Roa , F Jr Mayor , C Murga , L Pinilla , UB Kaiser , M. Tena-Sempere

Metabolism. 2022 Apr;129:155141. doi: 10.1016/j.metabol.2022.155141. Epub 2022 Jan 22. PMID: 35074314. https://www.metabolismjournal.com/article/S0026-0495(22)00019-1/fulltextBrief Summary: the authors used pharmacological and transgenic models to demonstrate the role of GRK2, G protein coupled-recept...

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ey0020.5-11 | Basic Research | ESPEYB20

5.11. Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

J Roa , M Ruiz-Cruz , F Ruiz-Pino , R Onieva , MJ Vazquez , MJ Sanchez-Tapia , JM Ruiz-Rodriguez , V Sobrino , A Barroso , V Heras , I Velasco , C Perdices-Lopez , C Ohlsson , MS Avendano , V Prevot , M Poutanen , L Pinilla , F Gaytan , M Tena-Sempere

Brief summary: A newly developed mouse model of congenital ablation of Dicer in kisspeptin neurons was used to identify a role for miRNAs in kisspeptin neuron activity and control of reproduction.The last few years have seen a shift in paradigm with the discovery of epigenetic mechanisms regulating GnRH neuron activity and thus puberty and reproduction. In particular, miRNAs appear to play a crucial role in the maturation and function of the hypothalamic...

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ESPE Yearbook of Paediatric Endocrinology

7.7. Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons

5.11. Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

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